الفهرس 
Hepatitis C virus infectionOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) is a major public health problem that can result in liver cirrhosis, HCC and in turn liver transplantation.
Egypt has the highest countrywide prevalence of (HCV) in the world and the probability that a person with chronic HCV will develop cirrhosis within 20 years is estimated to be around 10 to 20%.
This study was conducted on fifty seven patients with chronic hepatitis C and twenty six healthy people as control group attending out- patients clinic Shebien El-Kom Teaching Hospital from October 2015 to December 2015 . from these cases, Fifty three patients (92.9%) were diagnosed as responders to treatment with sofosbuvir and simeprevir and four patients (7.02%) were non responders to treatment. after 3 months of the end of treatment 50 (87,72%) of responding patients develop sustained virological response (SVR) and the other 3 patients were missed .
This study aimed to assess the possible role of IL-6 on response status of patients with HCV during treatment .
This study was found significant difference between patients as regards sex which responders were more males than females , and as regard age there was higher mean age for non-responders .
Concerning end of treatment response occur in 92.98% (53/57) of patients and SVR achieved in 87.72% (50/53) of patients , as 3 patients were missed .
In this study we found that significant difference between the two groups as regards Hemoglobin which was higher in responders than non responders , and as regards platelets which was higher in non responders than responders.
In this study we found that no significant difference between the studied patients as regards the blood glucose and WBCs .
This study was found that ALT , T. bil. and INR were significantly higher in non responders than responders but no significant difference as regards AST , Albumin and creatinine among the studied patients .
This study was found no significant difference was found among the two groups as regards the AFP and TSH.
Also no significant difference was found among the two groups as regards viral load.
Also this study found baseline IL-6 levels were significantly higher in patients (269.98 pg/ml) than control group (180.73 pg/ml) .
IL-6 levels before treatment were significantly higher in SVR (272.54 pg/ml) than non-responders (230.5 pg/ml) .
After treatment IL-6 were significantly higher in non-responders (164.5 pg/ml) than SVR (125.76 pg/ml) .
IL-6 levels decrease significantly after treatment in SVR .
There was negative correlation between IL-6 and platelets , white blood cells , alanine aminotransferase and INR and positive correlation with age , glucose , hemoglobin , aspertate aminotransferase , total bilirubin , albumin , creatinine , alpha feto protein , thyroid stimulating hormone and viral load however of non-significance .
ROC for IL-6 for prediction of response show the best cut-off point for IL6 was 233 pg/ml with a sensitivity of 70%, a specificity of 75% and a positive predictive value of 97.2 %, negative predictive value of 16.7 % and the area under the curve was 0.6604.