الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a genetically determined disease of the skin characterized by profound epidermal hyperproliferation and marked inflammation of epidermis and dermis, vascular changes and dermal inflammatory infiltrate. Many pathological features of psoriasis can be attributed to alternations in the growth and maturation of epidermal keratinocytes. Epidermal keratinocytes are also crucial to cutaneous inflammatory and immune responses in psoriasis by elaborating various cytokines, adhesion molecules, and chemotactic factors. However, the regulatory and effector mechanisms underlying epidermal andimmunological activation in psoriasis remain incompletely understood.
Recent concepts of the pathogenesis of psoriasis focus on the importance of the innate immune system and the role of dendritic cells, neutrophils, and antimicrobial peptides (AMP).
Various exogenous and endogenous factors such as streptococcal pharyngitis (with guttate psoriasis), stressful life events, humidity, Human Immunodeficiency Virus infection, trauma, smoking, drugs (beta-blockers, lithium, anti-malarial, Interferon), cold weather, diet and obesity have been shown to be associated with psoriasis
Psoriasis vulgaris is the most common variety of psoriasis, representing about 70% to 80% of psoriatic patients.
Psoriasis is associated with the complex disorder of metabolic syndrome, which incorporates hypertension, dyslipidemia, obesity, and impaired glucose tolerance.
Adipose tissue is an important endocrine organ secreting adipokines which have an important regulatory function throughout the body.
Omentin-1, 40 kDa fat depot-specific protein synthesized by visceral stromal vascular cells, has a paracrine role in modulation of insulin sensitivity and obesity. Plasma concentration of omentin is associated with endothelium-dependent vasodilation. Circulating omentin levels are negatively correlated with carotid intima-media thickness, which is a marker of early atherosclerosis. Low levels of circulating Omentin-1 are also associated with the prevalence of coronary artery disease.These data suggest that omentin may represent a biomarker for not only metabolic disorders, but also cardiovascular diseases.
Additionally, Omentin-1 exhibits powerful anti-inflammatory properties by inhibiting the inflammatory cytokine network and down-regulating TNF-α- induced expression of endothelial adhesion molecules.
The aim of the present work was to investigate serum level of omentin-1 innon obese patients with psoriasis compared with healthy controls.
The present study included forty five patientswith chronic plaque psoriasis and fifteen age and sex matched healthy subjects as a control group. Exclusion criteria included patients on topical therapy for psoriasis during the last four weeks prior to the study,patients on systemic therapy, subjects with obesity,smoking,diabetes mellitus, acute or chronic infections, malignancies, autoimmune disorders, andsubjects with cardiac, hepatic or renal diseases, polycystic ovary syndrome and dermatological disease other than psoriasis.
Patients and controls were subjected to history taking and clinical examination. BMI and waist circumference were measured. PASI score was calculated and serum omentin-1 level was measured using human omentin-1 ELISA kit.