الفهرس | Only 14 pages are availabe for public view |
Abstract In the last few years, there was an increased incidence of vasculitis in patients with thyrotoxicosis. Those vasculitic reactions ranged from simple purpuric skin lesion to sever intra-alveolar hemorrhage and even to Steven Johnson Syndrome (SJS). Most of those vasculitic reactions occurred in patients receiving propylthiouracil or methimazole (Noh et al., 2009 ).However, many other cases were detected in thyrotoxic patients not receiving those medications(Lee et al., 2007 ). In our study MPO-ANCA (p-ANCA)levels in plasma are evaluated as an indicator of vasculitis in 100 male and female thyrotoxic patients,25 Grave’s on treatment, 25 Grave’s on no treatment,25 thyrotoxic (nodular or multinodular) on treatment,25thyrotoxic (solitary nodular or multinodular) on no treatment, and a control group of 25 healthy subjects. All patients were subjected to detailed clinical examination and investigations which included CBC,T3, T4, TSH, CBC, ESR, ALT, AST, urine analysis, p- ANCAand anti-thyroglobulin antibodies. |