الفهرس 
Pathogenesis of Systemic Juvenile Idiopathic ArthritisOnly 14 pages are availabe for public view
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Abstract
Introduction: Juvenile idiopathic arthritis (JIA) is the most common inflammatory rheumatic disease in childhood, affecting one in 1000 children. JIA is characterized by severe joint inflammation in one or more joints, which persists for at least six weeks, with disease onset before the age of 16 years. This heterogeneous group of diseases can be divided into several subtypes on the basis of clinical symptoms, medical history, and abnormalities in laboratory measures.
Aim of the Work: This work aims to study the value of measuring the serum level of the soluble monocyte/ macrophage lineage cell marker CD163 in the early prediction of MAS in patients with SJIA through monitoring its levels, over a one year period, together with those of soluble CD25 versus other clinical and laboratory criteria of MAS. This will be achieved via following up patients with SJIA in the active state, in remission and those who go into MAS and comparing them with patients with other rheumatologic diseases complicated by MAS.
Patients and Methods: The study is a pilot exploratory prospective study conducted on 27 patients with SJIA followed up in the Pediatric Allergy and Immunology unit, Children’s Hospital, Ain Shams University. The 27 patients with SJIA were diagnosed based on the definition of ILAR classification of JIA. A group of 10 patients with MAS and 2ry HLH; and another group of 20 healthy children were studied as control groups.
Results: The results of the current study were tabulated and graphically represented in the following tables and figures. Tables including the basic data are annexed at the end of this study.
Recommendations: Further studies on larger scales to establish reference value for sCD163 as an early predictor of MAS in SJIA as well as a predictor of SJIA activity. Further studies on wider scale to establish the role and the predictivity of ferritin/ESR ratio for MAS secondary to SJIA.