الفهرس 
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Abstract
This study was a single-center, prospective, observational, randomized,, with 2 parallel arms that involved 50 babies, 26 babies were male (52%) and 24 female (48%) with mean gestational age 29.00±2.41 weeks, range between 28 to 34 weeks, and mean birth weight of 1.09±0.25 kilograms, range of 800 to 1625 grams. They were divided randomly into two groups (liberal group) and (restricted group) according to modality of therapy they received with 25 and 25 patients in each arm respectively. Following admission infants were randomized to the allocated treatment, (liberal or restricted), which was started after diagnosis of PDA with ECHO.Our aim to study the efficacy and safety of fluid restriction during management of PDA in preterm low birth weight infants compared with effect of liberal fluids.The results revealed that fluid restriction is better than liberal fluids in management of haemodynamically significant ductus arteriosus as detected in results of transductal diameter and circulating atrial natruitic peptide which decreased after restriction.Although there is a significant decrement of duct diameter after fluid restriction but the ducts are still patent and staged as moderate haemodynamically significant ductus arteriosus according to the staging system of Sehgal and MaNamara 2009.So our results does not support the hypothesis that fluid restriction has beneficial effects on pulmonary or systemic hemodynamics in preterm newborn with HSDA.