الفهرس 
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Abstract
Recurrent miscarriage is defined as three or more miscarriages before 20 weeks of gestation. Only 1% couples are affected by this problem which increases to 5% if couples with two miscarriages are included. Many causes have been implicated including chromosomal abnormalities, uterine structural anomalies, leuteal phase defects, thrombophilias, immunological and endocrinological causes. Even after evaluating the cause, in over 50% of cases it remains unexplained. How to treat such patients is a difficult situation for the physicians.
A combination of low-molecular-weight heparin and aspirin in recurrent miscarriage with antiphospholipid antibodie s has become a routine practice. This treatment with addition of progesterone is being commonly used for unexplained miscarriages in clinical practice without proper evidence.
Data from several non-randomized studies have suggested that attendance at a dedicated early pregnancy clinic has a beneficial effect, although the underlying mechanism is unclear. The success of thromboprophylactic treatment for women with recurrent miscarriage associated with APS has resulted in women with unexplained recurrent miscarriage frequently demanding similar treatment. Some clinicians have extrapolated the beneficial effect of aspirin and heparin therapy in women with APS to all women with recurrent miscarriage.
In our study 100 patients were selected with recurrent abortion and were investigated for causes of abortion and results showed no obvious cause of abortion. Those patients were divided into two groups first group (50 patient) was on prophylactic dose of cal heparin , aspocid and progesterone and the other group (50 patients) was on no treatment.
The fate of the two groups was observed regarding to occurrence of complications in the first trimester like abortion, missed abortion and its relation to the use of heparin and aspirin and the relation to the time of administration of the drug, age of patient, weight, number of previous abortions. Occurrence of complications of drug intake like bleeding from body orifices or thrombocytopenia.
In our study 21 patients in the group taking aspocid , calheparin and progesterone pass 1st trimester with incidence 42%. While 29 patients fail to pass 1st trimester with incidence 58%. While in the group not taking aspocid, calheparin and progesterone 18 patients pass 1st trimester with incidence 36%. While 32 patients fail to pass 1st trimester with incidence 64%.