الفهرس 
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Abstract
Summary and Conclusion
Helicobacter pylori is one of the most common human pathogens infecting an estimated 50% of the global population.In Egypt, the prevalence of H. pylori is estimated to be 50% in the 3 years age group and increasing to 90% in adults.
portal hypertensive gastropathy (PHG) represent important cause of chronic gastrointestinal bleeding, responsible for chronic blood loss anemia in 3–26% of patients with cirrhosis. The role of Helicobacter pylori (H. pylori) in the development of portal hypertensive gastropathy is still controversy.
The aim of this study was to ascertain the prevalence of Helicobacter pylori in patients with PHG and determine whether it contributed to the severity of the disease .
This prospective case control study was initiated on 30 cirrhotic patients with PHG were enrolled as cases and 30 cirrhotic patients without PHG were enrolled as controls. All the patients were subjected to complete history taking, clinical assessment, routine laboratory investigations and assessment of the severity of liver disease .Upper G I endoscopy was done to evaluate PHG. In addition biopsies were taken for rapid urease test to assess H. Pylori status.
In this study we found that the prevalence of H pylori was (46.7%) of cases , compared to (56.7%) of controls and the prevalence of H. pylori was higher in mild PHG compared to severe PHG.
Hence , we concluded that portal hypertensive gastropathy does not provide a favorable environment for the colonization of H. pylori. The decline in H. pylori positivity with the severity of PHG suggests that this bacterium is unlikely to contribute in the pathogenesis of PHG.