الفهرس 
HEPATO CELLULAR CARCINOMA
Annexin A2 in tumor invasion and metastasisOnly 14 pages are availabe for public view
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Abstract
Introduction: Among the 49 identified proteins, ANXA2 was selected to further histological and serological validation. ANXA2 belongs to a widely distributed, calcium-dependent, phospholipid-binding protein family. It is located on the surface of endothelial cells and most epithelial cells. ANXA2 has been implicated in many functions, for example, exocytosis, endocytosis, vesicle transport,regulating ion channels,immune response, cell–cell adhesions, mitogenic- and lipid-messenger-mediated signalling and fibrinolysis.
Aim of the work: The aim of this study is to determine the value of serum ANXA2 in the diagnosis of HCC in high risk patient(cirrhotic patient).
Patients and method: This study is conducted on 200 adult patients includes 80 adult patients with liver cirrhosis due to HCV infection with proved HCC, 80 adult patients with liver cirrhosis due to HCV infection &40 apparantly adult healthy individuals, all subjects underwent laboratory investigations include Complete blood pictures, Liver profile tests, Renal function tests, HCV :anti HCV antibodies by ELISA, Tumour marker :(measurement of serum AFP and ANXA2 by ELISA, Imaging studies (Abdominal ultrasonography, Triphasic spiral abdominal CT scanning in proved HCC patients).
Results: There was statistical significant decrease in hemoglobin (P<0.001), total leucocytic count (P=0.02), platelet count(P=0.002) in comparing between HCC & Crrhotic groups. There was statistical significant increase in blood urea & serum creatinine (P<0.001) in HCC & cirrhotic groups if compared to control group. There was statistical significant decrease in serum albumin(P=0.02), but with statistical significant increase in seum total bilirubin(P=0.046), AST, ALT, ALP(P<0.001) in comparing between HCC & Cirrhotic groups. There was statistical significant increase in serum AFP & ANXA2 in HCC & cirrhotic groups if compared to control group (P<0.001).
Conclusion: Serum ANXA2 may considered as agood and potent biomarker for diagnosis of HCC and is agood biomarker for HCC patients with normal AFP levels.