الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Objectives the aim of this study was to detect a relation between serum levels of interleukin – 22 (IL -22) in patients with psoriasis and also to detect a relation of IL-22 with psoriasis area and severity index (PASI). Background IL-22 is highly expressed in several different chronic inflammatory conditions, including psoriasis, multiple sclerosis and rheumatoid arthritis. The best studied function for IL-22 is within the skin as it has an inflammatory role during skin inflammation. Subjects and methods the study was conducted on 40 patients with psoriasis and 40 age-matched and sex-matched healthy individuals. All patients were subjected to history taking and complete medical examination serum level of IL-22were measured by enzyme-linked immunosorbent assay technique. Serum levels of IL-22 were statistically analyzed in relation to PASI. Result the serum levels of IL-22 were elevated in patients with psoriasis compared with healthy people (p< 0.023). the serum IL-22 was significantly higher in patients with severe psoriasis as compared with those with mild and moderate psoriasis. There was no statistically signification difference between the serum levels of IL-22 and disease duration. Conclusion the significant elevation in the serum level of IL-22 in patients with psoriasis when compared with that of healthy controls and the signification elevation in the serum levels of IL-22 playing a fundamental role in pathogenesis of psoriasis