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Abstract COLLAGEN MOLECULES ARE SECRETED from CONNECTIVE TISSUE CELLS AS PROCOLLAGEN, A BIOSYNTHETIC PRECURSOR OF COLLAGEN THAT COMPRISES THREE Α-CHAINS WITH ADDITIONAL N- AND C-TERMINAL EXTENSIONS. FIBRILS ARE FORMED from THE AGGREGATION OF COLLAGEN MOLECULES from WHICH THE PROCOLLAGEN PEPTIDES HAVE BEEN CLEAVED. The CXL technique is promising in treating corneal melting conditions or infectious keratitis because cross-linking would strengthen a collagenolytic cornea while UVA irradiation eliminates the infectious agent. Combination of ICR implantation with CXL seems to have a synergistic effect for reverting the progressive irregular astigmatism due to keratoconus or iatrogenic ectasia. A sequential or simultaneous combination of limited topography-guided PRK and CXL, whose goal is normalizing the cornea as much as possible, shows promising results |