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Abstract Regional anesthesia is a preferred technique for ophthalmic surgery. It is safe, inexpensive and provides efficient ocular anesthesia for ophthalmic surgery. Among regional blocks, peribulbar block is safer in comparison to retrobulbar block due to a lesser incidence of serious complications such as brainstem anesthesia, globe perforation, and retrobulbar hemorrhage. In order to enhance the onset of akinesia and increased tissue diffusion, additives like hyaluronidase, adrenaline, clonidine, corticosteroids, sodium bicarbonate and neuromuscular blocking agents have been used in peribulbar block. These agents are also not devoid of side-effects like allergic reaction, bradycardia, sedation, dryness of mouth, systemic neuromuscular blockade. Until date, no one adjuvant is ideal for peribulbar block. The aim of our study was to compare the effect of dexmedetomidine, fentanyl and magnesium sulfate when added to a mixture of lidocaine and bupivacaine on the quality of peribulbar block for cataract surgery. This study was a prospective double blind randomized controlled one; the total number of patients was equal to 200. The patients were randomly assigned to four equal groups (50 patients in each group). Peribulbar block was performed in all patients using total volume of 8.5ml, 7ml of the local anesthetic mixture of (1:1) as 3.5 ml of 0.5% bupivacaine and 3.5 ml of 2% lidocaine + (75 IU) hyaluronidase in 0.5 ml + 1 ml of the test drug, groups were classified as following: 1-group C (control group): Local anesthetic mixture + 0.9% sodium chloride (1 ml |