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Abstract Diabetic foot ulcers and their complications are an important cause of morbidity and mortality in patient with DM. These ulcers tend to heal slowly, need intensive care and healing can be complicated by infection and gangrene, leading to long term hospital treatment and /or amputation. Immunological defects in addition to neuropathy and vascular abnormality are the prime contributors in the pathogenesis of diabetic foot and subsequent infections. Vitamin D is a pleiotropic hormone known to play an immunomodulatory role in addition to Ca and bone metabolism, many studies have shown that deficiency of vitamin D leads to immune cell dysfunction. The aim of this work was to study the relationship between Vitamin D level and the risk of developing diabetic foot ulcer in type 2 diabetic patients. This study was conducted in Ain Shams university hospitals (DM outpatient clinic and inpatient ward, general surgery and vascular wards) from March 2016 to December 2016 on 60 adult subjects who were divided into 2 groups. All participants were subjected to an informed written consent, full medical history taking, general clinical examination and Laboratory investigations including serum (Creatinine, Ionized Ca++, phosphorus, Mg++, alkaline phosphates, AST, ALT and 25 hydroxy vitamin D level, HbA1c, triglycerides and total cholesterol). Patients with chronic systemic diseases such as renal failure, liver cell failure were excluded from the study |