الفهرس 
Intrapartum Fetal SurveillanceOnly 14 pages are availabe for public view
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Abstract
Introduction: Labour is a stressful event for the fetus but is well tolerated by most. However, in some infants stress of labour in terms of metabolic acidosis can lead to Hypoxic Ischemic Encephalopathy (HIE). HIE around term remains a major cause of neonatal mortality and morbidity with lifelong chronic disabilities. Such insults are not limited to high risk pregnancies but can also occur in about 50% of low risk pregnancies. On current evidence, it is estimated that in about 10 of brain damaged infants, the cause is hypoxia during labour.
There has been considerable interest in magnesium sulfate (MgSO4) because magnesium alleviates excitotoxic damage by binding to the magnesium site on the NMDA (N-methyl-D-aspartate) glutamate channel (Westermaier et al., 2013).
Aim of the Work: Magnesium sulphate (MgSo4) for fetal neuroprotection in patients presenting by intrapartum fetal distress at term.
Patient and Methods: A Randomized controlled trial (RCT). The current study will be conducted to single term pregnant women who develop intrapartum fetal distress (as defined later) and needs emergency CS (ceaseran section) according to Ain Shams protocol. This study was carried on 200 pregnant females, recruited from observation and labour wards of Ain Shams University Maternity Hospital. The current study will be conducted to single term pregnant women who develop intrapartum fetal distress and needs emergency CS (ceaseran section) according to Ain Shams protocol. We approached 200 single term pregnant women conducted at Ain-Shams University Maternity Hospital who develop intrapartum fetal distress and needs emergency CS (ceaseran section) according to Ain Shams protocol, to examine the effects of administered magnesium sulphate .patient were invited to participate in the study after providing clear explanation of the study and its expected values.
Conclusion and Recommendation: Magnesium sulfate is effective in reducing risk of Apgar score <7 at 5min. Magnesium sulfate appear to be effective in reducing seizure and NICU admission. Magnesium sulphate is associated with maternal morbidity rather than non exposure in the form of nausea and flushing. The improvement in short-term outcomes without significant increase in side effects indicate the need for further trials to determine if there are long-term benefits of magnesium and to confirm its safety.