الفهرس 
Thyroid and pregnancyOnly 14 pages are availabe for public view
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Abstract
There are some numbers of physiological changes that occur during pregnancy including thyroid function. Thyroid dysfunction during pregnancy is common with a prevalence of 2%–4% and it is associated with adverse maternal and fetal outcome. There are different trimestric reference ranges of thyroid hormones that differs according to the different geographical areas ethnic population and different technical laboratory parameters.
Objectives of the study: this study aimed to determine trimester specific reference intervals of the thyroid functions in normal pregnancies of Egyptian ladies.
Subjects and methods: this study was conducted on 360 women. Ladies were categorized into three groups according to the gestational age: group 1 included 120 subjects in the first trimester (was considered from weeks 1–12). group 2: included 120 subjects in the second trimester (was considered from weeks 13–27). group 3: included 120 subjects in the third trimester (was considered from weeks 28–40). Thyroid function tests (FT3, FT4 and TSH) were performed by ELIZA using enzyme immunoassay kits. Results: TSH value increased with advancing pregnancy from 1.43 ± 1.16 µIU/mL in the first trimester to 1.78 ± 1.19 µIU/mL in the third trimester and the difference between the first trimester and other trimesters was statistically highly significant. The free T4 level decreased from 1.16 ± 0.23 ng/dL in the first trimester to 0.98 ± 0.17 ng/dL in the third trimester and the difference was statistically highly significant. The free T3 level decreased from 3.18 ± 0.52 ng/dL in the first trimester to 2.79 ± 0.38 ng/dL in the third trimester and the difference was statistically highly significant.
Conclusion: The reference ranges are different from all previous studies outside Egypt showing that TSH was 0.01-3.5 µIU/ml, Free T3 was 2.41-4.05 pg/ml and free T4 was 0.7-1.51 ng/dl in the first trimester, while in the second trimester TSH was µIU/ml 0.2-3.01, free T3(2.14-3.4pg/ml and free T4 was 0.77-1.32 ng/dl and in the third trimester TSH was 0.92-2.78 µIU/ml ,free T3 2.29-2.99 pg/ml and free T40.78-1.09 ng/dl.