الفهرس 
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Abstract
In this study, we explored the marine algae distributed along 120 km and on depth of one meter from the intertidal zone on Safaga seashore along Red Sea through spring season (2015).
Samples of ten algal taxa were collected from which six algal species belonging to phaeophyta mainly Padina pavonica., Cystoseira barbata , Hydroclathurs clathratus, Sargassum latifolium, Dictyota dichotoma and Turbinaria ornate and, four species belonging to Rhodophyta, mainly Galaxaura oblongata, Acanthophora spicifera, Liagora farinosa and Digenea simplex.
A laboratory experiment was conducted to test antibacterial activity of ethanol extract of brown alga C. barbata against three types of Gram – positive , six of Gram –negative bacteria and fungus , where extract of this alga proved efficient activity against these pathogenic bacteria species ranged between medium and high suppression action.
The phycochemistry screening of the ethanolic extract of brown alga C. barbata showed the prescence of flavonoids, phenols and poly-saccharides, where are all these antioxidant compounds.
The current study aims to evaluate the protective effect of C. barbata. ethanolic extract against TAM-induced injury in female rats .
According to the study protocol twenty four animals were divided into four groups as follows:
group 1 (Normal): Rats received saline orally, daily for 4 weeks.
group 2: Rats received 100 mg/kg body weight of extract of algae cystoseira barbata suspended in 1% carboxymethylcellulose (CMC).
group 3: (TAM), rats were supplemented with 20 mg/kg/day TAM orally, daily for 4 weeks prior to scarification.
group 4: experimental group (TAM) rats were supplemented daily/ orally for 4 weeks with 100 mg/kg of extract of algae cystoseira barbata as well as 20 mg/kg of TAM then sacrificed.
At the end of experiment, rat were anesthetized by ether inhalation and blood samples were collected. Collected blood samples were left to coagulate then centrifuged at 3000rpm fo 15 minutes to separate serum.
Both FOXP1 and AKrb10 genes and there protein were significantly upregulated and ING3 was significantly downregulated in the liver of TAM treated rats compared to control rats.
Oral supplemation of C. barbata produced a significant down-regulation in the expression of FOXP1 and AKrb10 genes compared to TAM treated group, where ING3 expression was markedly upregulated.
Treatment of rat with TAM induced marked impairment of liver function evidenced by a significant elevation of serum AST and ALT compared to control group. Oral supplemation of C. barbata produced a significant decrease in the rate of enzymes ALT and AST.
The results revealed significant elevation in liver lipid peroxidation in the TAM-induced rats compared to the control group. In the contrary, GSH content and SOD activity in liver of the TAM-induced rats showed significant decrease when compared to control group. Moreover, treatment of TAM-administrated rats with C. barbata produced a significant elevation in GSH content and SOD activity and significant decrease in liver lipid peroxidation.
Also the histopathological examination of the TAM treated group revealed degeneration and necrotic changes as compared to control group, however, administration of algal extract showed marked amelioration of the severity of these changes.