الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The important role of radiotherapy after surgery in epidemiological study of adult STS patients and the efficacy of chemotherapy in local advanced and metastatic disease with recommendation for using target therapy in the future. Methods Clinical assessment of the patients through history, examination and laboratory and radiological investigation were collected and reviewed. Treatment includes: surgery, radiotherapy and chemotherapy; and the standard chemotherapy was based on anthracyclines as: doxorubcine (20 mg/m2 ) and ifosfamide (2gm/m2). Also, multiple lines of chemotherapy as: gemcitabine (900mg/m2) and docetaxel (75ng/m2) were used. Results : 90 non metastatic patients were refered after surgery and received adjuvant treatment in the form of radiotherapy and chemotherapy. During follow up time of 33 months, 46 of 90 eligible non metastatic patients showed failure of adjuvant treatment in the form of local recurrence in 31 patients and or distant metastases in 27 cases and only one case with LN mets and lungs were the commonest sites of metastases. About 51 patients died during the period of treatment. 31 patients died from disease itself and 20 patients died from other causes. Only 7 cases refered with metastatic from the start and received palliative surgery, radiotherapy and chemotherapy. DFS was 37% at 5 year and the estimated 5 year OS was 45%. The most common chemotherapeutic toxicities was hematological and grade 2 was the commonest. However, grade 4 toxicity was not reported. Conclusion : Radiotherapy after surgery has important role in treatment STS. Tumor site and size were indepentant predictors of metastases development. Information about DFS. OAS and the accepted chemotherapeutic toxicities were included.