الفهرس 
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Abstract
The main objectives of the present thesis are to:1. Evaluate the hepatoprotective effect of two different doses of curcumin against TAA-induced HCC in rat model.2.Assess the normal levels of autophagy and apoptosis and measure how they are affected by both TAA and curcumin through measuring of LC3-II genetic Introduction and Aim of the Work 3. expression,and SQSTM1 concentration as biomarkers for the autophagic process, and Bcl-2 genetic expression as a biomarker for apoptosis.4.Assess the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) as markers for oxidative stress and understand the relationship between reactive oxygen species (ROS) and autophagy.5.Evaluate autophagy in HepG2 cells under the effect of different doses of curcumin.This study aimed to investigate the effect of curcumin in protecting against thioacetamide (TAA)-induced HCC in rats.It mainly aimed to determine whether curcumin’s effect is attributed to autophagy or apoptosis.The study also aimed to investigate the effect that curcumin has on HepG2 cancer cells to make a connection between in vivo and in vitro results.