الفهرس 
Attention Deficit Hyperactivity DisorderOnly 14 pages are availabe for public view
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Abstract
Introduction: Many studies have given an increasing amount of attention to a possible role of brain derived neurotrophic factor in cognitive function and mental health. BDNF deficiencies have been linked with many neuropsychiatric disorders such as schizophrenia, Parkinson’s disease, Alzheimer’s disease, depression, and cognitive decline. Many studies showed that different levels of BDNF levels were significantly associated with the pathogenesis of ADHD in children. This study aimed to measure BDNF level in children diagnosed with attention deficit hyperactivity disorder and to identify the possible impact of BDNF level on severity of ADHD.
Methods: We investigated 60 children with ADHD. who were recently diagnosed and didn’t receive any medications, and 30 control children who were free from any medical or psychiatric illness. The study was carried out at the Institute of Psychiatry, Ain Shams University.
They were assessed using the sociodemographic history taking, semi-structured clinical interview for DSM-IV (KSADS) , trail making tests A,B and Conner’s parent’s rating scale for cases. Blood samples were obtained from the subjects and plasma BDNF levels were measured by ELISA.
Results: We found that there was a significantly higher plasma BDNF level in the ADHD group as compared to the control group, no significant correlation was found between BDNF status and the severity of ADHD symptoms.
Conclusion: BDNF level is higher in ADHD children as compared to healthy age and sex matched comtrols. It couldn’t be correlated tho the severity of ADHD symptoms. Also, there is no definite correlation between BDNF status and cognitive functions.