الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The present thesis is devoted to the development of highly advanced analytical methods for the assay of certain central nervous system (CNS) drugs, namely: levodopa (LDP), carbidopa (CDP), benserazide (BSZ), entacapone (ENT), selegiline (SGN), lisuride (LSD), pregabalin (PGN), gabapentin (GPN), vigabatrin (VGN), and baclofen (BCN), in pharmaceutical formulations and/or in biological fluids. The thesis comprises a general introduction about the CNS drugs and a literature review about their methods of analysis in different pharmaceutical, biological and environmental matrices. The thesis involves five electrophoretic separation methods for the simultaneous assay of binary, ternary and quaternary mixtures as well as enantioseparation of a chiral mixture. The methods involved a cyclodextrin-capillary electrophoretic method for the assay of six anti-Parkinson drugs in single and combined dosage forms. Moreover, three lab-on-a-chip electrophoretic methods were developed for the assay of binary or ternary antiepileptic gabapentinoids mixtures and/or GABA agonist drugs in pharmaceutical and biological matrices. The lab-on-a-chip methods are based on gel electrophoresis or cyclodextrin- electrokinetic chromatography on microchip platforms with application of stacking and dynamic pH junction as online preconcentration techniques to enhance the sensitivity of the proposed methods. At last, a chiral cyclodextrin-microchip electrokinetic chromatographic method was developed for the assay of BCN enantiomers in pharmaceutical formulations and biological fluids. The separation modes of the developed electrophoretic methods and the experimental conditions were intensively investigated and the validation parameters of the proposed electrophoretic methods were carefully studied. The results indicated the validity of the proposed methods to be applied for the assay of the studied analytes in pharmaceutical and biological matrices