الفهرس 
Follicular growth and maturationOnly 14 pages are availabe for public view
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Abstract
Background: infertility is usually described as the inability of a couple to conceive after one year of unprotected intercourse. Infertility is a major health problem affecting about 10-20% of couples.
Aim: it was to determine the cut-off value for E2/Number of follicles and E2/Number of M2 oocytes at an approximately equivalent sensitivity and specificity as a predictor for pregnancy after intra cytoplasmic sperm injection (ICSI).
Patients and Methods: this study was a Cohort study, conducted at Ain-Shams University El-Demerdash Hospital, IVF Center, from September 2016 till June 2017. We studied 82 cases and inclusion criteria included age range from 20-40 years old and sub fertile women undergoing long agonist protocol ICSI cycles. Exclusion criteria included severe male factor infertility and previous history of documented poor response resulting in mature oocyte <3 oocytes, the presence of a uterine pathology, recurrent pregnancy loss (≥3 previous miscarriages) and previous implantation failure (≥3 previous failed).
Results: there is significantly higher clinical pregnancy rate in patients <36 years old (39.3%) over those had 36-40 years old (9.5%) (P=0.011). Also there is significant difference between pregnancy rate at E2/M2 oocytes number ratio groups (P=0.049). The pregnancy rate was the least in E2/M2 oocytes number ratio between (195.10-254.75) pregnancy rate was 5.9% and the pregnancy rate was the highest in E2/M2 oocytes number ratio (>=254.76) (pregnancy rate 44.4%) but there is no significant difference between pregnancy rates at E2/follicular Number Ratio quartiles (P=0.336).
Conclusion: age is an important determinant of IVF success. There is a significantly higher clinical pregnancy rate in patients <36 years old over those from 36-40 years old, estradiol per mature follicle and retrieved oocytes do have an impact. Pregnancy rate is better when E2/M2 oocyte ratio is more than 254.76 pg/ml. In contrast, E2/Follicular number ratio dose not correlate with the outcome of the IVF cycles.