الفهرس 
chapter 1Only 14 pages are availabe for public view
 |  | from | 176 |  |  |
| | | from | 176 | | |
Abstract
The azo coumarin ligands and their transition metal complexes have been well documented in the literature as good antimicrobial, anticancer, antibacterial and antitumor agents. The current interest in coumarin ligands act as monobasic bidentate ligands coordinated via nitrogen atom of the azo group (-N=N-) and oxygen atom of the deprotonated phenolic OH group.
The main aim of the present thesis is focused on the preparation and characterization employing elemental analyses, thermal analysis (TGA), spectral (IR, UV-Visible, 1H and 13C-NMR) and magnetic measurements of new complexes of 3-Ethoxy-6-(phenyl azo)-7-hydroxy coumarin (LH1) and 3-Cyano-6-(p-chlorophenyl)aza-7-hydroxy coumarin (LH2) with Cu(II), Ni(II), Zn(II) and Mn(II).
A brief description of the overall work in this thesis can be summarized as follow:
Chapter one displays different publications concerning the complexation of coumarin compounds with a great attention to the compounds similar to that investigated and their biological activities.
The second chapter covers the experimental part and illustrates the experiments used in this work. It includes a list of reagents, stock solutions along with the physical measurements and instrumentation. The working procedures for the preparation of the ligands and their metal complexes.
Chapter three deals with the results and discussion which are summarized to give the following information:
Summary
2
The proposed chemical formulae of HL1 and HL2 and their metal complexes are in good agreement with the stoichiometries concluded from their analytical data of carbon, hydrogen, nitrogen, chloride and metal contents.
All complexes have high melting points (>300˚C) and insoluble in most organic solvents.
The coordination sites of the ligands, the nature of metal-ligand bonds and the existence of the solvated molecules have been elucidated using IR spectra. Different modes of chelation for the investigated ligand are suggested based on careful comparison between the spectra of the ligands and their corresponding complexes.
Detailed thermal analysis for the prepared complexes was performed in the temperature range 30-800 or 1000˚C. The thermograms show the decomposition steps after which a constant weight is observed corresponding to the remaining part of the complex.
The thermodynamic activation parameters of decomposition processes of the ligands (HL1), (HL2) and their Cu(II), Ni(II), Zn(II) and Mn(II) complexes namely activation energy (Ea), enthalpy (ΔH*), entropy (ΔS*), and Gibbs free energy change of the decomposition (ΔG*) were evaluated graphically by employing the Coast-Redfern and Horowitz-Metzger methods.
The molecular structures and bonding parameter of the compounds have been calculated.
Summary
3
Molecular docking was used to predict the binding between azo compounds with the receptor of breast cancer 3hb5-oxidoreductase and prostate cancer mutant 2q7k–Hormone.
The calf thymus DNA binding activity of the ligands and their metal complexes were studied by absorption and viscosity spectra.
The antitumor activity of ligands their metal complexes was tested against human cancer MCF-7 (breast cancer).