الفهرس 
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Abstract
The present investigation was carried out at the department of bee research, plant protection institute, Sakha–Kafer EL-Sheikh province and department of pharmacognosy, faculty of pharmacy, Mansoura University during the period from the beginning of January 2014 to the end of December 2014. The study includes measurement of bee activity in collecting and producing honey, propolis and bee venom according to bee race, in a comparative study between Carniolan hybrid and Italian hybrid. For one year and study of some biological and chemical properties and ATR-FTIR spectral analysis (infrared) of some bee products (honey, bee venom and propolis) and their effects on three types of cancer cells (HepG-2, Caco-2 and MCF-7) in a comparative study with the effort of two drugs (5Fu and Cis-pt) in different concentrations. The study dealt with the following points. The average amount of clover and cotton honey yield/colony (9.57, 5.30 kg/colony respectively) produced by Carniolan hybrid colonies was higher than that (8.30, 5.14 kg/colony respectively) produced by Italian hybrid colonies, The highest moisture percentage was recorded from unripe clover honey. (Kafer EL Sheikh 2015) and ripe Brazilian pepper honey; reached to 22.1% of total soluble solids 77.9%,while The lowest moisture was recorded from rip Acasia honey, reached to 16.1% with total soluble solids 83.9%, the ripe Clover honey Kafer Elsheik 2015samples showed six plant spices of pollen grains, The total amount of bee venom produced by Italian hybrid colony was 1.2719 gm/colony/year, while the total amounts of bee venom produced by Carniolan hybrid were 1.2509 gm/colony/year, The total amount of propolis gathered by Carniolan hybrid colony was 46.93 g/colony/year, while the total amount of propolis gathered by Italian hybrid was 20.76 g/colony/year. The results showed that, Italian dissected method-bee venom was the most active among all the tested samples against HepG-2 (93.92%), Caco-2 (93.92%) and MCF-7 (90.17%). However, Libyan propolis proved to be most active among all tested propolis samples. On the other hand, all tested honey samples showed non-remarkable activities except Asyut-clover honey (49.84% against Caco-2 cell line). In honey, the highest total phenolic was 121.628 mg / 100 gm in cotton honey, the highest value of invertase was 8.8 in the honey of medical plants, the highest value of diastase was 19.7 in the honey of medical plants, The highest value of the catalase enzyme was 24.8 in the honey of medical plants, The highest value of hydroxyl methyl furfural was 6.8 mg / kg in the market honey.In bee venom, The highest value of Melittin was 68.12% in Carniolan venom (dissected method), the highest value of Phospholipase was 15.37% in the Carniolan venom (dissected method), the highest value of hyaluronidase was 2.94% in the venom of carnivores (electric shock). In propolis, The highest value of total phenolic compounds was 121.958 mg / 100g in Bulgarian propolis, The highest value of Caffeic acid was 2.56 mg / ml in Bulgarian propolis, the highest values of cinnamic acid was 30.8 mg / ml in Bulgarian propolis, the highest value of ferric acid was 2.65 mg / g in Bulgarian propolis, The highest antioxidant activity was 38.7 mg / ml in Bulgarian propolis.