الفهرس 
Content
Status Migrainosus TreatmentOnly 14 pages are availabe for public view
 |  | from | 111 |  |  |
| | | from | 111 | | |
Abstract
Migraine is a common disabling primary headache disorder. Epidemiological studies have documented its high prevalence and high socio-economic and personal impacts. It is now ranked by the World Health Organization as number 19 among all diseases world-wide causing disability. (10)The current study was designed for three objectives, firstly; to study the vascular changes that occur in migraine during and in between the attack , secondly to see if the associated EEG changes has a relation to Migraine , and finally to study the soft neurological signs in migraine patient. This study was done throughout the period from January 2016 to January 2017. The study was carried out in Assiut University hospital , neuropsychiatric department.In this study, 30 patients having migraine with aura and 30 controls were included. The ages of all patients varied between 16 and 49 years, the means of age + SD was (31.5+9.6). The number of male patients was 7 (23.3%) and 23(76.7%) female patients as shown in table (1). The 30 controls were 9 males (30%) and 21 females (70%), there ages varied between 16 years and 60 years, the means of age + SD was (28.5+8.1) as shown in table (1).Transcranial Doppler examination was performed within 6 hours of the migraine attack and in the headache-free period (at least 96 hours after the last migraine attack) and within 6 hours of the migraine attack.The anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), vertebral artery (VA) and basilar artery (BA) were insonated pulsatiliy index and mean velocity were measured.Also an EEG was done to both the patient (during the migraine attack) and to the controls. Soft neurological signs assessment was done to both the patient and controls. There were significant difference between headache free and the headache phase in all arteries on both sides (decrease in the mean velocity and increase in the pulsatility index (PI) by paired sample t-test )as shown in table (7).The decrease in the mean velocity and the increase in the pulsatility index are due to increase resistance to arterial blood flow due to constriction during the first 6 hours of the migraine attack .Also The EEG recorded changes have significant relation to migraine as 50% of migraine cases show abnormal EEG record compared to 16.7% in controls, these abnormalities were mainly epileptiform in nature showing bursts of sharp-slow wave complexes33.3% ,sharp wave brusts 16.7% or slow waves 13.3%. Those changes were either generalized (93.34% of abnormal EEGs) or focal (6.66%).Only two cases show positive soft neurological signs (sensory and visuospatial station) while no soft neurological signs were detected in the control so the migraine has no effect on the soft neurological signs. Our study concluded that the migraine is associated with vascular changes that occur during the attack and relived after receiving the treatment and electroencephalographic changes during the migraine attack.