الفهرس 
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Abstract
Introduction: ID and IDA are worldwide health problems and one of the most common medical situations seen in daily practice. ID refers to the decrease in Fe stores which precedes overt IDA or continue without progression. IDA is a more severe situation in which low levels of Fe result in anemia with microcytic hypochromic red cells. The aim of work: To assess the antioxidant status and its possible impact on changes in serum hepcidin level which may affect iron metabolism in children with iron deficiency anemia. Research Plan: All cases as well as controls were clinically evaluated, and had subjected to laboratory assessment of; CBC ,serum iron, total iron binding capacity , serum ferritin level , serum hepcidin level and estimation of serum total antioxidant capacity . Results: Serum iron showed significant decrease in case group than control group . On the other hand TIBC was significantly higher in case group than the control group, while serum ferritin was significantly lower in case group than control group, Regarding serum hepcidin it was higher in case group when compared with control group, on the contrary TAC was significantly lower in case group than control group, Case group was divided into two subgroup according to serum hepcidin level subgroup A hepcidin>50ng/ml) and subgroupB( hepcidin< 50 ng/ml). TAC was found to be lowered in subgroup A than subgroup B andTAC was found to be decreased and hepcidin was found to be increased in the case group below 10th percentile of weight for age when compared to those above 10th percentile of weight for age. Conclusion: The elevated hepcidin level in more than 50% of studied cases and lower TAC together with paradoxical negative correlation between serum iron and serum hepcidin in IDA patients indicates that hepcidin level is controlled not only by serum iron level but also other factors like antioxidative and nutritional status should be considered. These factors may interfere with successful iron therapy in patients with IDA.