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Abstract Hepatitis C virus (HCV) is a major public health worldwide. HCV is characterized by a high genetic diversity and variability, which leads to a rapid viral escape from cellular and humoral immunity that leads to persistence of HCV as chronic HCV infection which is a common cause of developing hepatocellular carcinoma (HCC). Dendritic cells (DCs) are the highly potent professional APCs that play a key role in primary immune responses, tolerance and maintenance of immune homeostasis. Thus, DCs-based vaccination has the potential to make a difference in cancer treatment and may constitute an efficient and important antiviral therapy for HCV. |