الفهرس 
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Abstract
This thesis consists of two parts each part contains two chapters:Part I consists of two chapters: in chapter one, we have three different methods (kneading, co-evaporation and freeze drying) to prepare meloxicam-cyclodextrin complexes (β-CyD and HP- β-CyD). The superior method was co-evaporation. In addition, preparation of different formulae include; eye drops, eye gels and ocuserts by using different polymers, study physical evaluations and in-vitro release of drug. The prepared ophthalmic preparations showed drug content complying with pharmacopeial limits, pH values tolerated by the eye, and acceptable viscosity limits. Generally, meloxicam complexation with each of HP-β-CyD and β-CyD increased the drug solubility.
The complexation of MX particularly with HP-β-CyD greatly enhanced its release compared with the uncomplexed drug. The drug release was affected by the formulation nature in the following order; Drops > ocuserts > gels.The improvement of MX release was dependent on the polymer type and was in the order of; HPMC > Sod. CMC > Sod. ALG from eye drops and eye gels, while, the release of MX from ocuserts was in the following order; Sod. CMC + CP940 > Sod. ALG. + CP940 > HPMC + CP940. In chapter two, we were selected three different formulae for evaluation of bioavailability of the drug in different eye tissues and aqueous humor. Ocular bioavailability of the drug in all eye tissues and aqueous humor from the tested formulations, was found to be in the following order; ocuserts > eye gels > eye drops. Relative bioavailability was increased from 1.22 to 6.50 folds for all tested formulations in different eye tissues and aqueous humor.Part II (chapter 1): includes the preparation of different formulations (microemulsions, in-situ gel systems and ocuserts) contained 0.3% of gemifloxacin mesylate by using different polymers and study the physical evaluations and in-vitro release of drug. A slower drug release from the prepared microemulsions was obtained with lower Smix concentration and higher oil content. In accordance, the release can be arranged in the order of FM2 > FM1 > FM3. In chapter 2, we selected three formulations to study the bioavailability of drug in different eye tissues and aqueous humor. The peak time of maximum drug concentration in rabbits’ eye tissues and aqueous humor was 3 hrs for ophthalmic in-situ gel and ocuserts and 5 hrs for ophthalmic microemulsions versus 1 hr for GEM solution as a control. selected formulations provided the maximum concentration of the drug in conjunctiva followed by cornea, iris-ciliary body then aqueous humor.