الفهرس 
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Abstract
The present study was carried out to illustrate whether INHα-16 C>T polymorphism is a determinal causative factor in development of premature ovarian failure among Egyptian women; with particular focus on the role of a number of related other reproductive hormones in this context. Subjects included in this study constituted 100 cases presenting patients with POF and control. The patient group included 50 women with sign and symptoms of POF based on stopped menstruation for at least 6 months with elevated serum FSH level (FSH ≥ 40 IU/l) and poor response during gonadotropin ovarian stimulation when they undergo IVF technique. Control group that included 50 women are normally menstruating, without family history of POF or early menopause, but undergo IVF due to male factor infertility. All subjects were recruited from the gynecological and Obstetric Department, Mansoura University, Egypt. The present study indicated that number of oocytes was significantly decreased in POF women in compared to control group. Also, results of hormonal assay showed that all women with POF exhibited significant increase in FSH and LH hormone levels compared to level in the control women. Moreover, Estradiol (E2), progesterone hormone and AMH showed low levels in POF women in comparison to the control group. The patient group also showed significantly decreased serum inhibin level and inhibin/activin ratio when compared to control group, and the results of the current study reveal non-significant change of serum activin in the patient group in comparison to the control group. At molecular level, the homozygous genotype CC, the heterozygous genotype CT, and the homozygous genotype TT, showed no significant differences in the genotype distribution of women with POF related to control group in genotype CT and in genotype TT. Also the present study indicated that, C and T alleles, showing non-significant differences in the allelic distribution between the two studied groups.from the previous results, the study concluded that INHα -16C>T polymorphism of gene cannot imply a functional effect on the current decline of serum inhibin and hence the risk of developing POF in the studied Egyptian women. Further studies on POF women are needed to expand the present data.