الفهرس | Only 14 pages are availabe for public view |
Abstract Idiopathic thrombocytopenic purpura (ITP) is a disorder that can lead to easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets , the cells that help blood clot Immune thrombocytopenia (ITP) is autoimmune destruction of platelets in addition to suppression of platelet production by the bone marrow (BM) megakaryocytes. The diagnosis of ITP depends on demonstration of a platelet count < 100 × 109/L and may be found in isolation (primary) or alongside other autoimmune and medical conditions (secondary) . Interleukin-23(IL-23) is proinflammatory cytokine among the four heterodimeric cytokines of IL-12 family. Interleukin 23 (IL-23) is a heterodimeric pro-inflammatory cytokine comprising IL-12 subunit p40 and IL-23 subunit p19. IL-23 is secreted by activated dendritic cells and macrophagesand is a crucial member in the innate immune system. The aims of this study was to evaluate the role of IL-23 in diagnosis of Idiopathic thrombocytopenic purpura. A total of 5 papers were obtained using the mentioned keywords in the research of all internet-based databases. The total number of cases in all of the studies was 239 cases. The mean age was recorded in 5 papers, and the mean age of each of them was 32.8 years. 107 There are different method of detection of IL23 in different study such as PCR ,ELISA and flow cytometry These findings suggest that levels of IL-23 are significantly higher in ITP patients. Conclusion In conclusion, the results of our research suggest that the levels IL-23 are significantly higher in ITP patients. |