الفهرس 
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Abstract
Bimetallic nanoparticles of silver (Ag) and gold (Au) were synthesized at room temperature using Curcumin. Reduction process of silver and gold ions with different molar ratios leads to production of different nanostructures including alloys and core-shells. Produced nanoparticles were characterized simultaneously with UV/visible, FTIR spectroscopy, transmission electron microscopy (TEM), and Energy-dispersive X-ray (EDAX). UV/vis. optical absorption spectra of as synthesized nanoparticles reveals presence of surface palsmon resonance (SPR) of both silver at (425nm) and gold at (540nm) with small shift and broadness of gold band after mixing with resucing and capping agent in natural extract which suggest presence of bimetallic nano structure (Au/Ag). FTIR and EDAX data approve the presence of bimetallic nano structure combined with curcumin extract. TEM micrographs shows that silver and gold can be synthesized separately in the form of nano particles using curcumin extract. Synthesis of gold nano particles in presence of silver effectively enhance and control formation of bi-metallic structure. The biological application was carried out to investigate the potential effects of synthesized bimetallic nanoparticles of silver and gold on breast cancer DMBA-induced in female albino mice . Female mice were divided into 5 groups , the first group acted as control group , the second group subjected to cancer induction , the third group exposed to radiation after cancer induction , the fourth group treated with nanoparticles after cancer induction and the fifth group treated with nanoparticles and exposed to radiation after cancer induction. Results showed significant increase in breast index of untreated breast cancer group and the group exposed to radiation after induction of cancer due to tumor incidence, whereas, the groups treated with nanoparticles even exposed or not exposed to radiation revealed significant decrease in breast index due to reduction of tumor incidence. Biochemical analysis exhibited increase levels of liver and kidney functions in groups treated with nanoparticles. Histopathological analysis revealed formation of tumor masses in breast tissue of untreated cancer group . Whereas, group exposed to radiation after cancer induction showed relative reduction in tumor masses. Moreover, group treated with nanoparticles after cancer induction revealed reduction of tumor incidence with less pathological changes. While, group treated with nanoparticles and exposed to radiation showed reduction in tumor incidence with marked pathological alterations.