الفهرس 
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Abstract
Isolated Coronary artery ectasia (ICAE) is considered an uncommon angiographic finding with varying patterns of presentation and carries significant morbidity burden to the patient.
The underlying pathology of Isolated Coronary Artery Ectasia (ICAE) still remains unknown; however, endothelial dysfunction (ED) may be responsible for the disease process which supports the hypothesis that atherosclerosis may be involved in the pathogenesis of coronary ectasia. Hyperlipidemia may have a key role in the disease process.
The aim of this study is to Assess of endothelial function in patients with Isolated coronary artery Ectasia (ICAE ) in comparison to patients with normal coronary arteries (NCA) by using Flow mediated dilatation (FMD) in the brachial artery .
The current study was conducted at Minia university hospital during period from August 2016 and March 2017. This study included includes 60 patients who underwent coronary angiography at catheterization Lab at Minia university hospital. Out of the total, 30 patients had Isolated Coronary Artery Ectasia (ICAE) while 30 age- and sex-matched subjects with normal coronary angiograms were used as a control group.
All patients in this study were subjected to:
• Coronary Angiography
Isolated coronary artery ectasia (ICAE) was defined as dilatation of at least one epicardial coronary artery 1.5 times the reference vessel diameter and absence of critical stenosis (≥ 50%) in any of the coronary arteries . NCA was defined as the absence of angiographic atherosclerosis.
• Flow-Mediated Dilatation ( FMD )
Brachial artery endothelium-dependent FMD which is non-invasive parameter of endothelial function, and correlates significantly with invasive testing of coronary endothelial function, as well as with the severity and extent of coronary atherosclerosis .
• Laboratory investigation
Serum level of lipid profile and renal functions .
This study demonstrated that isolated coronary artery ectasia (ICAE) group had lower values of flow mediated dilatation ( FMD ) showing endothelial dysfunction ( ED ) and higher serum levels of cholesterol and low density lipoprotein cholesterol ( LDL ) and triglycerides ( TG ) and relatively lower serum levels of high density lipoprotein cholesterol ( HDL ) .
Finally, we proved that patients with Isolated coronary artery ectasia have more severe endothelial dysfunction than patients with normal coronary angiography, which supports the hypothesis that atherosclerosis may be involved in the pathogenesis of coronary ectasia. Hyperlipidemia may have a key role in the disease process.