الفهرس 
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Abstract
Psoriasis is a chronic inflammatory and immune-mediated disorder that affects nearly 2–4% of the general population. In addition to a geneticpredisposition, it has various vascular and immunological abnormalities. It is now believed that psoriasis is not merely a skin disease but is a systemic inflammatory disorder, and other organs, including vascular system, may be affected by the chronic inflammation.
Specifically, people with more severe presentations of psoriasis appear to have an increased frequency of psoriatic arthritis, cardiovascular disease (CVD), hypertension, obesity, and diabetes; other immune-related disorders, such as Crohn’s disease; and an excess risk of mortality. Further, psoriasis patients often suffer from depression The etiology of psoriasis remains unclear, although the critical pathogenic role of effector T cells, as well as key pro-inflammatory cytokines, such as tumour necrosis factor (TNF), interleukin-23 (IL-23), and IL-17, have been firmly established. Interactions between dendritic cells, T cells, keratinocytes, neutrophils, and the cytokines released from immune cells likely contribute to the initiation and perpetuation of the cutaneous inflammation that is characteristic of psoriasis.
The ‘‘sunshine’’ vitamin (Vitamin D) is a hot topic that attracted ample attention over the past decades. Vitamin D insufficiency and deficiency are now recognized as a global problem, affecting a large percentage of the general population. A growing evidence shows that populations who are deficient in 25-hydroxyvitamin D (25(OH)D) have higher risks for several cardiovascular related disorders such as diabetes mellitus, obesity, hypertension, carotid arterial disease, impaired arterial stiffness, myocardial infarction, heart failure, and ultimately mortality.