الفهرس 
Risk factors of breast cancer :-
Breast cancer intrinsic subtypes:-Only 14 pages are availabe for public view
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Abstract
Neoadjuvant chemotherapy is the standard care for treatment
of locally advanced and inoperable breast cancer. Application of this
systematic therapy before surgery benefits patients with improved
rates of breast-conserving surgery, increased possibility of early
measurement of response, as well as potentially preferable outcomes
for certain subgroups of high-risk patients (183 ) .
Neoadjuvant chemotherapy (NAC) is often a first line of
defense in the treatment of locally advanced breast cancer.
Administered prior to surgery, neoadjuvant chemotherapy can reduce
tumor extent, increase a patient’s surgical options, and reduce
metastasis (184).
The ideal outcome of NAC is the complete absence of
residual invasive tumor cells within excised breast tissue following
NAC, or pathological complete response (pCR), which strongly
predicts favorable prognosis as compared with patients who
experience partial or no response (non-pCR) (185,186).
About 10 – 50% of breast cancer patients who undergo NAC
achieve pCR, depending on receptor status subtype (187) and thus
there is a need for reliable noninvasive pretreatment predictors of
pCR that can enable better targeting of NAC and prevent a delay in
effective treatment for patients with non responding or progressive
tumors.Neoadjuvant chemotherapy is the standard care for treatment of
locally advanced and inoperable breast cancer.
Response to neoadjuvant chemotherapy is affected by several
factors such as ; demographic factors , histopathological factors and
breast denisty.
Patient with low breast density are more likely to achieve complete
and partial response to neoadjuvant chemotherapy.
Other factors affect response to neoadjuvant
chemotherapy as , age less than 40 , low body mass index ,
premenopausal women , tumor grade 1 , no lymphovascuar
invasion , no multicenteric tumor are more likely to achieve
complete and partial response..
Treatment modalities also affect complete and partial response , in
our study patients treated with anthracycline and taxenes achieve
response than patients received anthracycline only or taxenes only.