الفهرس 
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Abstract
The chemistry of 1,3-oxazolones had received great attention in the last decades. The importance of these compounds is due to facile opening of the oxazolone ring to give acyclic products which can recyclize again to afford varieties of heterocyclic systems of synthetic and biological importance.
The original work of this thesis can be classified into four parts:
Part 1: In this part, the 6-amino pyrazolo[1,2-a][1,2,4]triazines-4,8-diones derivative 3 was synthesized. Then it was reacted with several electrophiles to form novel pyrazolotriazine derivatives.
Part 2: In this part, some of the obtained compounds in part 1 were evaluated against their antitumor activity.
Part 3: In this part, the cyanoacetohydrazide derivative 16, pyrazolone derivative 17 and pyridin-2-one derivative 25 were prepared and used as synthons for the construction of Schiff’s bases, chromenone, tetrazolopyrazolone, pyrazol-one, pyran-2-one and triazolopyridine derivatives.
Part 4: In this part, some of the obtained compounds in part 3 were evaluated against their antimicrobial activity.