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Abstract Conclusion SPECT CT imaging modality is a novel imaging technique that combine low dose CT with planner scintigraphy aiming to identify both avid and non-avid lesions giving the physician higher precision in disease evaluation and staging. SPECT/CT improved the detection and localization of LN metastases and distant metastases compared with whole-body scintigraphy and had a considerable effect on the management of patients with well-differentiated thyroid carcinoma. The therapeutic plans were altered in 10 (9.2%) of 108 patients on the basis of the SPECT/CT findings. Patients with higher serum TG and higher risk stratification would be the target patients who may have great benefit for adding SPECT/CT technique to their scans especially when whole body imaging is negative or equivocal. Recommendation On the basis of our study findings, it is recommended that SPECT/CT should be routinely performed in the evaluation of high-risk well-differentiated thyroid carcinoma patients after radioiodine therapy or during routine follow up especially if serum thyroglobulin is significantly elevated. |