الفهرس 
ACKNOWLEDGEMENT
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Abstract
Based on the accumulating data and the previous several studies that showed the effect of BM-MSCs on liver regeneration we designated our study that included 40 patients with the mean age of (57) years old that randomly assigned into 2 groups:
• group 1:(The study group) included 18 patients(13 males and 5females) who received hepatocyte like cells differentiated from autologous MSC via ultrasound guided percutaneous portal veininfusion plus regular conventional treatment, and
• group 2: (control group) included 22 patients (14 males and 8 females) who received regular conventional treatment only.
The results of our study showed improvement in quality of life that was assessed by using performance status score through the follow up period that was significant in treated patients than in control group.
Also we detected improvement in liver synthetic functions (serum bilirubin, serum albumin and to some extent improvement in INR), some clinical manifestations as (grade of ascites, lower limb edema and to some extent frequency of hepatic encephalopathy attacks) which was also significant in patients of study group than in control group. We also detected significant decrease in Child score and the mean level of MELD score in G1 than in G2.
However, we detected minimal changes in G1 before and after treatment regarding liver function (improvement was in serum albumin only). There was considerable improvement in lower limb edema, frequency of variceal bleeding and hepatic encephalopathy attacks and minimal improvement in grades of ascites.
Most of our results regarding the pervious parameters were detected to be in the maximum improvement at 3 months of follow up period with some parameters were to some extent hardly could maintained until the end of the study (6 months).
Our results showed no differences between both groups regarding SBP, hepatorenal syndrome or HCC development.
The technique we used in our study was safe and feasible with no portal vein thrombosis development or major side effects detected through the follow up period of the study.
Our data showed no mortality rate detected in the study group through follow up period. In contrast in control group; 2 patients died at 12 and 14 weeks respectively after the beginning of the study because of uncontrolled bleeding (variceal bleeding).