الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
The use of natural polyphenols for chemoprevention is a promising approach for inhibition of cancer growth and proliferation. Studies have suggested a cancer protective effect of ellagic acid, but the results obtained are so far not conclusive. In the current study, the apoptogenic effect of ellagic acid on an Ehrlich ascites carcinoma (EAC) cell line in situ was investigated. Mice were intraperitoneally administered EAC cells (1x106) to develop ascitic tumors and are used as a control group. Oral administration of 50 mg/kg ellagic acid resulted in a significant increase in survival rate, with a decrease in the viability of tumor cells and ascitic packed cell volume of EAC. In addition, ellagic acid induced cell cycle arrest at G0/G1 and apoptosis. These effects were supported by the finding of inhibition of CD1, PARP, and Ki67, activation of p53, caspase-3, and Bax and downregulation of Bcl-2 levels in EAC cells. The redox status in the treated EAC cells showed a significant increase in the levels of GSH, SOD, and CAT were increased and MDA content was decreased. The efficacy of ellagic acid in modulating redox status through induction of apoptosis and inhibition of cell proliferation and cell cycle arrest demonstrated that polyphenols can modulate the response of tumor cells reflecting the therapeutic potential of ellagic acid.