الفهرس 
IntrodictionOnly 14 pages are availabe for public view
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Abstract
English Summary
This study was conducted upon 60 patients diagnosed to suffer from Type II diabetes mellitus according to American diabetic association (ADA). Patients were recruited from outpatient and inpatient clinic of Internal Medicine Department of Beni-Suef University. Patients constituted from 29 males and 51 females where their ages ranged between 23 to 76 years old with a mean age of 45 years old. Results illustrates that there is no statistical significant difference with p-value >0.05 between cases and control as regards sex and age distribution which indicated proper matching between both studied groups. Comparisons of investigations in different studied groups had been perform that there is statistically significant difference with p-value <0.05 between cases and control as regards hemoglobin, HbA1c, urea, creatinine, and A/C ratio with low mean of hemoglobin and high mean of HbA1c, urea, creatinine, and A/C ratio among diabetic patients. On the other hand, there is no statistically significant difference with p-value >0.05 between cases and control as regards sodium and potassium level. Simile of serum progranulin in different studied groups clarify that there is no statistically significant difference with p- value >0.05 between cases and control as regards serum progranulin which indicated no impact of diabetes on serum progranulin level in the beginning of the disease. Rapprochement of fundus and neurological examinations in different studied groups explicate that there is statistically significant difference with p-value <0.05 between cases and control as regards results of fundus and neurological examination with high percentage of Non- proliferative diabetic retinopathy (NPDR), and positive peripheral neurological finding among cases of diabetes (In the form of negative vibration sense test and monofilament test. Correlation between serum progranulin in studied diabetic group stated that there is no statistically significant correlation with p-value >0.05 between serum progranulin and any of other variables in the study among diabetic patients. Arbitrage of serum progranulin in different gender among diabetic group cleared that there is no statistically significant difference with p-value >0.05 between different gender as regards serum progranulin which indicated no impact of sex on serum progranulin level. Compare between serum progranulin in fundus examination and neurological examination among diabetic group illustrates that there is no statistically significant difference with p-value >0.05 between different fundus examination results as regards serum progranulin which indicated no impact of it on serum progranulin level. On the other hand, there is statistically significant difference with p-value <0.05
between different neurological examination results with high mean among patients with positive neurological examination. Detection of the sensitivity and the specificity of serum progranulin in diagnosis of microvascular and neuropathic complications among type II DM patients cleared that probability of being true positive is (53%) more than being false positive when repeat test 100 times with sensitivity (81.5%) and specificity (37.7%) while sensitivity and specificity test for serum progranulin in detection of neurological complication spell that probability of being true positive is (63.8%) more than being false positive when repeat test 100 times with sensitivity (75%) and specificity (52.5%).
In conclusion, This study el uci d at e d for the first time that serum PGRN concentrations increased in Egyptian patients during presence of several microvascular complications, constructed that PGRN is considered as a biomarker for diabetic microangiopathy and its severity as well as it is serum level was increased due to close relation with the progress of diabetic microangiopathy as well as subsequently proved that PGRN level in diabetic patients suffered from type 2 diabetes should be owing high sol ic i tu de f o r di ag no si s a nd f o ll o wi ng u p a nd results fundamentals that PGRN level could be u sed as a potential therapeutic target for management.