الفهرس | Only 14 pages are availabe for public view |
Abstract It is well established that DPN is a complex condition that has many consequences. There are varied clinical presentations of diabetic neuropathy with involvement of proximal or distal peripheral sensory and motor nerves, as well as autonomic nerves. The early recognition of neuropathy is important to reduce morbidity and mortality and to improve quality of life. This study was conducted on two groups of diabetic patients, either type 1 or type 2, receiving diabetes education and medical treatment selected from Alagouza charity Hospital between 2015 and 2016. •group (1): 40 diabetic patients without clinical detectable symptoms of peripheral neuropathy of short duration (≤ 5 years duration of diabetes mellitus). •group (2): 40 diabetic patients with clinical detectable symptoms of peripheral neuropathy of long duration (>5 years duration of diabetes mellitus). Each of the studied groups was subjected to history taking, clinical examination, laboratory investigations including serum glucose, HbA1c, serum level of interleukin 6 (IL-6) and neurological tests including nerve conduction studies, vibration test and monofilament test. In this study, we compare serum level of IL-6 in diabetic patients with asymptomatic peripheral neuropathy of short duration (≤ 5 years duration of diabetes mellitus) and in diabetic patients with symptomatic peripheral neuropathy of long duration (>5 years duration of diabetes mellitus). We studied the relation between the relation between nerve conduction studies of motor and sensory nerves and the serum level of IL-6 in diabetic patients. In our study, serum level of IL-6 in diabetic patients with symptomatic peripheral neuropathy of long duration is higher than diabetic patients with asymptomatic peripheral neuropathy of short duration. Serum level of IL-6 shows statistically significant negative correlation with motor and sensory nerve conduction velocities which is higher in diabetic patients with symptomatic peripheral neuropathy of long duration than in diabetic patients with asymptomatic peripheral neuropathy of short duration. In our study, it has proven that interleukin 6 (IL-6) has a role for detection of diabetic peripheral neuropathy. We suggested that serum level of interleukin 6 (IL-6) can be used as diagnostic marker for diabetic peripheral neuropathy. |