الفهرس 
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Abstract
The aim of the present work is to design and synthesize some new bioactive heterocyclic systems starting from 2-substituted-quinoline-3-carbaldehydes 1a and 1b as important synthons and to evaluate the biological activity of the new compounds as well. The present work is planned to investigate the behavior of 1a and 1b towards various reagents. Therefore, the sequences of these reactions followed for the synthesis of the designed compounds in this thesis are summarized in Schemes 1-8. The original work of the thesis is subdivided into three parts: Part 1: Chemical reactivity studies This part is subdivided into two sections: Section 1: Convenient synthetic approaches to binary and fused quinoline-cored heterocycles. Section 2: Adequate transformation reactions of quinoline Schiff bases to five- and six-membered heterocyclic rings. Part 2. Biological Evaluation Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. and antioxidant agents using DPPH and H2O2 radical scavenging assays Part 3. Geometrical optimization It was carried out using the density functional theory (DFT) via cluster calculations using DMOL3.