الفهرس 
PALNOnly 14 pages are availabe for public view
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Abstract
Background: Uncontrolled postoperative pain may produce a range of detrimental acute and chronic effects. The attenuation of perioperative pathophysiology that occurs during surgery through reduction of nociceptive inputs to the central nervous system (CNS) and optimization of perioperative analgesia may decrease complications and facilitate recovery during the immediate postoperative period and after discharge from the hospital.
Objective: The aim of the work is to study efficacy of perioperative pregabalin for postoperative pain relief in patients undergoing simple lumbar laminectomy
Patient and Methods: After approval of the local ethical committee and having an informed consent from every patient, this study was carried out in Matarya Teaching Hospital.
Results: The current study was carried out on eighty patients ASA physical status I and II, scheduled for elective lumbar laminectomy without fusion under general anaesthesia. They were randomly allocated into the two equal groups using the closed envelope technique.
Conclusion: from the present study, the following can be concluded: Pregabalin has been demonstrated to have analgesic efficacy after lumbar laminectomy, Pregabalin prevented the increase in heart rate and arterial blood pressure associated with surgical stimulation, Pregabalin reduce the analgesic requirements and postoperative opioid use and The use of pregabalin could have higher patient satisfaction.