الفهرس 
Chronic Hepatitis C Virus infectionOnly 14 pages are availabe for public view
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Abstract
YKL-40 is it is an inflammatory glycoprotein involved in endothelial dysfunction by promoting chemotaxis, cell attachment and migration, reorganization, and tissue remodeling as a response to endothelial damage.
Liver fibrosis is caused by an imbalanced remodeling process due to chronic inflammation associated with excessive scar tissue formation. Hepatic stellate cells (HSC), key players in this process, transform from quiescent cells into proliferative, fibrogenic and contractile myofibroblast-like cells in response to growth factors.
Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease.
The aim of the work was to assess serum level of YKL_40 in patients with chronic hepatitis C as a marker for the degree of liver fibrosis. A comparative study was done between YKL_40 and two liver fibrosis indices in the pateint group.
This study included 87 subjects, 77 pateints with chronic hepatitis C and 10 healthy volenteers as a control group.The included subjects were classified into 2 groups.
Patient group
Subgroup1:(patients with degree of fibrosis less than or equal 2).This group include 28 patients ,14females and14 males and subgroup 2: (patients with degree of fibrosis more than 2).This group include 49 patients,28 females and21 males.
Control group: this group included 10 healthy volunteers with matched age and gendre with the diseased group, (5) males and (5) females.