الفهرس 
THE PATHOLOGY OF BREAST CARCINOMAOnly 14 pages are availabe for public view
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Abstract
A !though there is evidence produced m vitro for an
human tumors including
of on effective in vivo
immunological reactivity against
breast carcinoma. The existence
antitumor response is still a matter of debate. (R. D. Leek,
/996)
The histological demonstration of lymphocytic
infiltration in breast carcinoma has been interrupted as an
indication of the host’s effmt to resist tumor growth. The result
of investigation regarding the prognostic value of breast cancer
infiltrating lymphocytes were controversial. Whereas some
authors were able to correlate lymphoid infiltrates to more
favorable clinical cot1rse of carcinoma. Others could not
confirm this. (R. D. Leek, 1996)
This study was designed to study relationship between
central necrosis & macrophage infiltration in both node
negative, node positive patient & patient survival as possible
prognostic indicator.
This cohort study will be conducted on 40 patient with
node (ve), (+vc) breast cancer in Ai1i Shams university hospital
the results of this study showed that there is significant
association between macrophage infiltration ( M I ) and patient
relapse in both lymph node (+ve) & (-ve) were p < 0.001
when Ml > 12 HPF as an independent prognostic variable .
These data indicate a role for. macrophage iri prognosis of cancer breast ai1d that this cell type may represent an important
target for immunoinhibitory therapy in breast cancer. The
results also showed no significant difference between ( M I ) & .
Age of patients, pathological type & tumor grading asP= 0.29
’ P= 0.40 ’ P= 0.06 respectively. While there was a significant positive conelation between high M I & tumor size > 2 em P
< 0.001 & also Positive significant Conelation between (+ve)
L.M & high M 1 P = 0.003 .
The results also showed comparison of central necrosis
with other prognostic Variables. Central necrosis compared to
other patients and tumor variable including age, tumor size,
tumor grading, Ml and pathological type, no significant
associations were evident.
Also Ill this results there is positive significant
associations between the presence of necrosis and node status p = 0.03.
The result also showed companson between patients
relapse with other prognostic variables a number of significant
associations were observed including:
- Positive association between lymph node status & patient
relapse ( P < 0.00 I ). And patient relapse to tumor size P =
0.004.
There is no significant difference between tumor !:,Tfading
and aged of patients to patient relapse