الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Budesonide is a potent glucocorticoid drug. It is used effectively for the treatment of irritable bowel disorders especially left sided colitis. The presence of drug in crystalline form, its poorly aqueous solubility, and targeting position at the distal end of GIT making a big challenges against formulation techniques. This thesis was concerned with the design and characterization of budesonide-loaded Eudragit S 100 nanocapsules. In the first, preformulation studies including fundamental physical properties of budesonide were determined. Budesonide-loaded polymeric nanocapsules were prepared, all the prepared samples were characterized regarding of particle size, zeta-potential, encapsulation efficiency, and in-vitro drug release. All studied batches were in nanoscale range and the observed particle size was within 130-500 nm with good stability behavior confirmed by higher zeta-potential values of -46 mV. Nanocapsules having higher encapsulation efficiency reached to 94% with good drug controlling and lower initial rapid release behavior. Animal studies showed good improvement.