الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
This study was conducted in order to eva lu ate serum concentra ti on of pro cal citonin in the
newborn infants as a predictor of neon atal sepsi s, and its value as a pararr.eter to follow up
septic inflamm ati on and to estimate progr1osis and success of th erapy .
For this purpose, 40 newborn infants presenting with symptomps and signs suggesting neonatal sepsis
admi tted to Neonatal Intensive Care Unit of Mansoura Gen eral H0spital (20 of them ha ve
positive blood cu lture resu lts, wh:;e the rem ainin g had negative cu lture resu l ts) were
en rollee! in the stud y . In add ition, 20 health y newborn infants of comparable
age and sex were included as controls.
A ll the study population were subjected to history tDk ing, clinica l examination , compl ete
blood coun t (tota: and differenti al l eukocytic count, liT & JIM rati os of granulocytes, and
platelet count), erythrocyte sedim entation rate (ESR), qualitative m easurement of CRP, X-ray
chest for cas(:.S w ith respiratory di stress, blood cu ltu re, CSF examination and cultu re for
cases w ith su spected m eningitis.
Quantitation of plasma procalcitonin (Pro-CT) level by Radioimmunoassay was done. Two consecutive
samples were obtained for both patient groups; the first sample was obtained at the time of
diagnosis of sepsis, and the second follow up sample was obtained Iweek later.
The majority of cases of neonatal seps1s, were without localization, some had pneumonia,
meningitis, and others with skin infection.
Respiratory distress and .lethargy & poor suckling and mottling were the commonest presentation of
sepsis in our study, followed by GIT manifestations and convulsions, while apnea was the l east
presenting symptom of sepsis.
Regarding laboratory diagnostic criteria of neonatal sepsis, normal total leukocytic count was a
common finding, some had leukocytosis, others had leukopenia. Bandemia (
400/mm 3
was found in 17 cases (42.5%), while 23 cases
(57.5%) had normal band cell count. liT ratio 0.2 was found in 16 cases (40%), 1/M ratio 0.3 in 12
cases (30%). Thrombocytopenia was a common finding.
Quantitation of plasma procalcitonin (Pro-CT) level by Radioimmunoassay was done. Two consecutive
samples were obtained for both patient groups; the first sample was obtained at the time of
diagnosis of sepsis, and the second follow up sample was obtained Iweek later.
The majority of cases of neonatal seps1s, were without localization, some had pneumonia,
meningitis, and others with skin infection.
Respiratory distress and .lethargy & poor suckling and mottling were the commonest presentation of
sepsis in our study, followed by GIT manifestations and convulsions, while apnea was the l east
presenting symptom of sepsis.
Regarding laboratory diagnostic criteria of neonatal sepsis, normal total leukocytic count was a
common finding, some had leukocytosis, others had leukopenia. Bandemia (
400/mm 3
was found in 17 cases (42.5%), while 23 cases
(57.5%) had normal band cell count. liT ratio 0.2 was found in 16 cases (40%), 1/M ratio 0.3 in 12
cases (30%). Thrombocytopenia was a common finding.