الفهرس 
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Abstract
SUMMARY
Necrotizing enterocolitis is an acute inflammatory disease of the intestine that primarily affects preterm infants and is a significant cause of mortality and morbidity in this population with incidence of 10 % of preterm infants and a mortality rate close to 30 %. Also, NEC may have up to a 25 % risk of significant neurodevelopmental impairment. Specific features of NEC include an underdeveloped gastrointestinal mucosal barrier, immature innate and humoral immunity, uncoordinated intestinal peristalsis, and pathogenic bacterial overgrowth.
The biomarker is a specific molecular indicator that can be used to identify or measure the progress of a disease and many potential biomarkers have been studied for their potential relevance to NEC. Many previous attempts have been made to identify biologic markers for the early detection of NEC.
Human pigment epithelium-derived growth factor (HPEDGF) is a multifunctional secreted protein with 50 kDa protein found in vertebrates (also known as SERPIN F1 and HPEDGF)and has anti-angiogenic, anti-tumorigenic and neurotrophic functions. It belongs to a vast family of peptides which provoke a variety of biological responses in the gastrointestinal tract, the majority of which involve regulation of cell replication and cell movement and survival. Also, it produces a variety of biological responses, such as enhanced proliferation and differentiation of epithelial cells.
This study is a case -control one included 80 newborns ,were classified into two groups:
group (I): Included 50 neonates diagnosed as Necrotising Enterocolitis (NEC).
group (II): Included 30 apparently healthy neonates as a control group.
The aim of this study was to detect urinary protein of human Pigment epithelial –derived growth Factor (HPEDGF) as a biomarker for early detection and diagnosis of Necrotising Enterocolitis (NEC) in neonates.
The results are summarized as follows:
There is highly significance difference between patient and control groups in age and weight. There was no statistically significant difference between patient and control groups in sex.
The present results revealed that urinary human Pigment Epithelium-Derived Factor concentration was significantly higher in patients group (10.78 in patients group vs. 6.77 in control group).
There was a strong significant positive correlation between CRP and level of HPEDGF (r=0.62, p. = 0.00).
The present results showed that urinary human Pigment Epithelium-Derived growth Factor has high sensitivity in diagnosis of NEC (98%) and the high specificity (73.3%).