الفهرس | Only 14 pages are availabe for public view |
Abstract Pneumonia constitutes a major proportion of the global burden of childhood disease, being responsible for around 20% of childhood deaths, the majority of which occur in developing countries .Childhood community-acquired pneumonia accounts for between 30% and 40% of hospital admissions with associated case fatality rates of between 15% and 28%. The World Health Organization (WHO) estimates there are 156 million cases of pneumonia each year in children younger than five years, with as many as 20 million cases severe enough to require hospital admission. Pneumonia is a condition typically associated with fever, respiratory symptoms, and evidence of parenchymal involvement, either by physical examination or by the presence of infiltrates on chest radiography. Our study included 90 children years admitted to Menofyia University Hospitals from December 2015 to April 2016. 60 of patients were included as cases aging from 5 month to 5 years. They were admitted patients suffering from pneumonia and for treatment of community acquired pneumonia.Patients were diagnosed based on clinical, laboratory and radiological findings and 30 apparently healthy children within same age ,sex and socioeconomic status .All were exposed to the same clinical assessment and laboratory investigations. The aim of the this study is to determine the levels of proadrenomedullin in a group of hospitalized children with pneumonia, and studying the relation between ProADM level and severity and complication of pneumonia. All cases were subjected to a complete clinical study (thorough history and physical examination) upon study inclusion, with emphasis on symptoms and signs of pneumonia. The following investigations were performed: chest x- ray complete blood counts (CBC), HB, WBCs, quantitative C-reactive protein (CRP), and serum Proadrenomedullin by a commercial enzyme linked immunosorbent assay (ELISA) kit. The study reached the following: Serum Proadrenomedullin level is significantly higher in pneumonic children compared to healthy controls. Serum Proadrenomedullin level is significantly higher in complicated children with pneumonia compared to noncomplicated cases. Serum Proadrenomedullin level is significantly higher in pleural effusion in complicated pneumonic children compared to patient without pleural effusion. Serum Proadrenomedullin level is significantly higher in severe pneumonic children compared to mild and moderate pneumonic cases. Serum Proadrenomedullin significantly more accurate than total leukocytic countand CRP in pneumonic children Serum Proadrenomedullin is more prognostic than diagnostic marker in pediatric pneumonia |