الفهرس 
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Abstract
Onychomycosis is a fungal infection of the fingernails or toenails that causes discoloration, thickening, and separation from the nail bed. The causative organisms could be dermatophytes, yeasts or non-dermatophytic fungi. Dermatophytes especially of genus Trichophyton account for most of the cases, other pathogens like Candida and non dermatophytic molds are more frequent in countries with hot and humid climate.
Purpose: To evaluate the efficacy of tazarotene as a single topical treatment modality for onychomycosis.
Patients and Methods: The present study is a clinical interventional study, conducted on 80 patients with finger(s) and/or toe(s) nail onychomycosis (OM). These patients were recruited from the outpatient clinic of dermatology department at Ain Shams University Hospitals, during the period from January 2016 till October 2017.
Results: Our study included eighty patients with clinical and mycological-confirmed onychomycosis. All patients were recruited from the Dermatology Outpatient Clinic at Ain Shams University Hospitals during the period between January 2016 to October 2017. All patients were informed about the study and an informed consent was obtained; however, ten patients withdrew their consent and subsequently they were completely eliminated from the study.
Conclusion: The antifungal activity of Tazarotene is of moderate potency and is comparable to some of the commercially available topical antifungal. Owing to its modest efficacy, we cannot support its use as a single treatment in cases of OM.