الفهرس 
DemodexOnly 14 pages are availabe for public view
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Abstract
Demodex folliculorum and D. brevis are obligatory parasites in the hair
follicles and in the pilosebaceous glands of human skin.
Demodex mites, which feed upon the epithelial cells of the hair follicle
or of the pilosebaceous gland, do not cause clinical symptoms in the majority
of infested individuals.
The mites are generally found on the forehead, molar areas of the
cheeks, nose and nasolabial fold, but can occur anywhere on the face or
around the ears, and occasionally on other parts of the body.
The prevalence of Demodex mites in healthy adults varies between
23.5% and 100%.
An increased number of Demodex mites were observed in dermatosis
such as rosacea, SD, perioral dermatitis, and eosinophilic folliculitis.
Rosacea is one of the diseases located in sebaceous gland-rich areas.
Although the roles of vascular and immunological alterations, reactive oxygen
species, chemical and ingested agents, influence of the weather, dermal
matrix degeneration, anomalies of the pilosebaceous unit and bacterial and
parasitic agents have been suggested, the Pathophysiology of rosacea is not
completely understood.
Another disease that is located in sebaceous gland-rich areas is SD. In
the etiopathogenesis of SD, many causes, including increased sebum activity,
androgen associated hormonal factors, immunological abnormalities, genetic
predisposition [HLA-AW30, AW31 and B12], emotional stress, neurological
disorders, fungal infections, nutritional deficits; lifestyle, environmental factors, pitrosporum ovale infection, drugs and D.folliculorum have been
suggested.
Several studies in the literature suggest a possible link between D.
folliculorum and rosacea and SD.
The aim of this study was to evaluate the role of D.folliculorum in SD.
and rosacea.
This case control study was conducted on 90 patients and subjects and
both sex. They divided to group A, it included 30 patients of SD, group B
included 30 patients of rosacea and group C included 30 patients of
apparently healthy subjects as control group.
Exclusion criteria: Subjects with any other dermatological lesions known
to be associated with demodex infestation, Subjects used tea tree oil or antiscabetic
preparation and Subjects received systemic anti parasitic,
immunosuppressive drugs, radiotherapy, chemotherapy or isotretinoin during
the last month prior to the study will exclude.
Patients and controls were subjected to history taking, clinical
examination and deep skin scraping. Deep skin scraping was taken from
Seborrhoeic area (check, nose, and forehead). The scrapings will preserved in
70% alcohol then cleared in 10% KOH to be examined microscopically for
detection of Demodex mite.
The present study showed that Demodex sampling was positive in 6
patients in group A (20%), 6 patients in group B (20%) and 0 in group C with
a statistically significant difference (p=0.020) between the three groups.