الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
POAG is due to decrease in the aqueous outflow facility due to
increased resistance to aqueous outflow as a result of thickening and sclerosis of
trabecular meshwork, narrowing of inter trabecular spaces and deposition of
amorphous material in juxtra canalicular space. It is characterized by slowly
progressive raised IOP, wide angle of anterior chamber , characteristic optic
disc cupping and specific visual field defects.
One hundred and twenty eyes with primary open angle glaucoma were
enrolled in this study. They were classified into two equal treatment groups
each of 60 eyes: group (A) received Alph2 agonist with -adrenergic blocker
(brimonidine tartrate 0.2% + timolol maleate 0.5%, respectively) twice daily
and group (B) received carbonic anhydrase inhibitor with -adrenergic blocker
(dorzolamide 2% + timolol maleate 0.5%, respectively) twice daily. IOP was
measured in the baseline (1st day) and in the follow-up period (1st week, 1st
month and 6th month).
Intergroup comparison of both groups shows a significant reduction in
IOP. In group A there was a reduction by 37.19% (from 24.95 to 15.67mmHge)
i.e 9.28mmHge. In group B there was a reduction by 38.41% (from 25.33 to
15.6mmHge) i.e 9.73.
There is a statistically highly significant between the first day and the
sixth month follow up period (P <0.01) in both groups. While the comparison
between the two studied groups in the initial of the study and at each of the
follow up periods (1st week, 1st month and 6th month) were statistically
insignificant (P > 0.05).
As regard the changes in visual acuity during treatment of the two
studied groups. The intergroup comparison of treatment shows insignificant
improvement in visual acuity in both groups. There is a statistically significant changes between the first day and the sixth month follow up period
(P >0.05) in both groups, also the comparison between the two studied groups
in the initial of the study and at each of the follow up periods (1st week, 1st
month and 6th month) were statistically insignificant (P > 0.05) as regard VA in
both groups.
As regard the changes in visual field during treatment of the two studied
groups as regard the mean deviation (MD) and the pattern standard deviation
(PSD). The intergroup comparison of treatment shows insignificant
improvement in mean deviation in both groups. There is a statistically nonsignificant
changes between the first day and the sixth month follow up period
(P >0.05) in both groups, also the comparison between the two studied groups
at each of the follow up periods (1st month and 6th month) were statistically
insignificant (P > 0.05) in both groups.
As regard the changes in nerve fiber layer (NFL) in m during treatment
of the studied groups as regard mean and pattern standard deviation (PSD). It is
noted that there is decrease in NFL thickness in all retinal quadrants in this
study in both combination groups from the baseline (1st day) to the end of
follow-up period (6th month). However, this reduction in NFL thickness was not
statistically significant comparing between both study groups, while they are
statistically significant in the intergroup study (i.e. each individual group).