الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a chronic inflammatory skin disorder affecting 1–3% of the population. It is associated with impairments in health related quality of life even in mild cases, and excess mortality in severe cases.
Psoriasis is characterized by epidermal hyperproliferation, abnormal keratinocyte differentiation, angiogenesis with blood vessel dilatation, and excess Th-1 and Th-17 inflammation. Increasingly, associations between psoriasis and metabolic diseases such as obesity, diabetes, and cardiovascular disease have been recognized.
Epidemiological studies have established these associations and increasingly they are determining the directionality of the associations and the role of psoriasis as an independent risk factor for these outcomes.
Similarly, advances in the knowledge of the pathogenesis of these seemingly diverse diseases have discovered common physiological pathways that may provide the biological plausibility of the associations discovered through epidemiological studies.